Tetrahydrobenzothiophene inhibitors of hepatitis C virus NS5B polymerase

A novel series of selective HCV NS5B RNA dependent RNA polymerase inhibitors has been disclosed. These compounds contain an appropriately substituted tetrahydrobenzothiophene scaffold. This communication will detail the SAR and activities of this series.

A series of tetrahydrobenzothiophenes have been prepared and identified as potent inhibitors of HCV NS5B polymerase. R = 6,6-Dimethyl, R′ = CONHSO2Ar.Figure optionsDownload as PowerPoint slide