Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents

We report the discovery of potent agonists for the human formyl-peptide-like 1 receptor (hFPRL1). These compounds did not act at a closely related receptor denoted human formyl peptide receptor (hFPR) up to 10 μM concentration. Recent studies have indicated that agonizing this receptor may promote resolution of inflammation. In an exploratory study, a novel hFPRL1 agonist showed efficacy in a mouse ear inflammation model following oral administration.

The discovery of potent agonists for the human formyl-peptide-like 1 receptor (hFPRL1) is reported. Recent studies have indicated that agonizing this receptor may promote resolution of inflammation. Following oral administration, a representative compound showed efficacy in a mouse ear inflammation model.Figure optionsDownload as PowerPoint slide