کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377954 | 981991 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Potential inhibitors of the Trypanosoma cruzi dUTP nucleotidohydrolase were docked into the enzyme using the program FlexX. Compounds that docked selectively were then selected and synthesized using solid phase methodology, giving rise to a novel library of amino acid uracil acetamide compounds which were evaluated for enzyme inhibition and anti-parasitic activity.
We report the in silico design and subsequent synthesis and biological evaluation of a novel class of uracil amino acid conjugates as potential anti-parasitic compounds.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 14, 15 July 2006, Pages 3809–3812
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 14, 15 July 2006, Pages 3809–3812
نویسندگان
Orla K. Mc Carthy, Alessandro Schipani, Alex Musso Buendía, Luis M. Ruiz-Perez, Marcel Kaiser, Reto Brun, Dolores González Pacanowska, Ian H. Gilbert,