کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377957 | 981991 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and antibacterial evaluation of ureides of Baylis–Hillman derivatives
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
The synthesis of several 1-(2-cyano-3-aryl-allyl)-3-aryl-urea(thiourea) constructed from the reaction between allylamines generated from Baylis–Hillman acetates and substituted isocyanates and isothiocyanates has been described. Further, their cyclization in the presence of a base led to the formation of 5-arylmethyl-4-imino-3-aryl-3,4-dihydro-1H-pyrimidin-2-ones. All compounds were tested for their antibacterial activity. Few of the compounds showed superior activity or were equipotent to the standard antibacterial agents.
The antibacterial activity of the (thio)ureas and 4-imino-3,4-dihydro-1H-pyrimidin-2-ones obtained from acetyl derivatives of Baylis–Hillman adducts is reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 14, 15 July 2006, Pages 3824–3828
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 14, 15 July 2006, Pages 3824–3828
نویسندگان
Somnath Nag, Richa Pathak, Manish Kumar, P.K. Shukla, Sanjay Batra,