3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity

Previously, chemistry effort on the gem-cyclohexane series of γ-secretase inhibitors has focused on the 4-position of the cyclohexane ring. Recently chemistry has been directed towards the 3-position and substitution here has also provided compounds with high γ-secretase activity.

The synthesis, biological activity and conformational analysis of 3-substituted gem-cyclohexanes based on 1 have provided compounds with high γ-secretase activity.Figure optionsDownload as PowerPoint slide