کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377986 | 981992 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of novel, non-acidic 1,5-biaryl pyrrole EP1 receptor antagonists
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Replacement of the carboxylic acid group in a series of previously described 1,5-biaryl pyrrole EP1 receptor antagonists led to the discovery of various novel non-acidic antagonists. Several analogues displayed high binding affinity and high binding efficiency indices.
The discovery and SAR of novel non-acidic 1,5-biaryl pyrrole derivatives is described. Several new motifs were discovered that were found to be effective replacements for the carboxylic acid in a series of EP1 receptor antagonists.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 5, 1 March 2007, Pages 1200–1205
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 5, 1 March 2007, Pages 1200–1205
نویسندگان
Adrian Hall, Stephen Atkinson, Susan H. Brown, Iain P. Chessell, Anita Chowdhury, Gerard M.P. Giblin, Paul Goldsmith, Mark P. Healy, Karamjit S. Jandu, Matthew R. Johnson, Anton D. Michel, Alan Naylor, Jennifer A. Sweeting,