کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1378005 | 981992 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
3-Substituted-(5-arylfuran-2-ylcarbonyl)guanidines as NHE-1 inhibitors
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 3-Substituted-(5-arylfuran-2-ylcarbonyl)guanidines as NHE-1 inhibitors 3-Substituted-(5-arylfuran-2-ylcarbonyl)guanidines as NHE-1 inhibitors](/preview/png/1378005.png)
چکیده انگلیسی
The C-3 substituents effect on NHE-1 inhibitory activity of (5-arylfuran-2-ylcarbonyl)guanidines, previously identified as potent NHE-1 inhibitors, was investigated. The introduction of amine or alkyl groups at the 3-position of the furan ring, next to the acylguanidine moiety, remarkably improves NHE-1 inhibitory potency. Especially the important finding is that 5-(2,5-dichloro)phenyl and 5-(2-methoxy-5-chloro)phenyl derivatives exhibit high NHE-1 inhibitory activities (IC50 < 0.02 μM) that match those of 3-unsubstituted derivatives.
The synthesis and evaluation as NHE-1 inhibitors of 3-substituted-(5-arylfuran-2-ylcarbonyl)guanidines is described.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 5, 1 March 2007, Pages 1291–1295
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 5, 1 March 2007, Pages 1291–1295
نویسندگان
Sunkyung Lee, Taemi Kim, Byung Ho Lee, Sung-eun Yoo, Kyunghee Lee, Kyu Yang Yi,