Quinazoline and benzimidazole MCH-1R antagonists

We have modified the previously reported 2-aminoquinoline 1 to provide two novel series of MCH-1R antagonists. Representative compounds from the quinazoline and benzimidazole series have been shown to be potent and selective, with promising in vitro eADME profiles.

The discovery, synthesis, evaluation and structure–activity relationships of a series of quinazolines and benzimidazoles as MCH-1R antagonists are described.Figure optionsDownload as PowerPoint slide