کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1378030 | 981992 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening](/preview/png/1378030.png)
A high-throughput screening campaign of a library of 100,000 lead-like compounds identified 2-iminobenzimidazoles as a novel class of trypanothione reductase inhibitors. These 2-iminobenzimidazoles display potent trypanocidal activity against Trypanosoma brucei rhodesiense, do not inhibit closely related human glutathione reductase and have low cytotoxicity against mammalian cells.
A high-throughput screening campaign of a library of 100,000 lead-like compounds identified 2-iminobenzimidazoles (L) as a novel class of trypanothione reductase inhibitors. These 2-iminobenzimidazoles display potent trypanocidal activity against Trypanosoma brucei rhodesiense, do not inhibit closely related human glutathione reductase and have low cytotoxicity against mammalian cells.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 5, 1 March 2007, Pages 1422–1427