کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1378031 981992 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ac2-DPD, the bis-(O)-acetylated derivative of 4,5-dihydroxy-2,3-pentanedione (DPD) is a convenient stable precursor of bacterial quorum sensing autoinducer AI-2
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Ac2-DPD, the bis-(O)-acetylated derivative of 4,5-dihydroxy-2,3-pentanedione (DPD) is a convenient stable precursor of bacterial quorum sensing autoinducer AI-2
چکیده انگلیسی

Ac2-DPD, the bis-(O)-acetylated derivative of 4,5-dihydroxy-2,3-pentanedione (DPD), was prepared both as a racemic mixture and in the optically active form found in naturally occurring DPD. It was shown to exhibit the same ability as DPD to induce bioluminescence in Vibrio Harveyi and β-galactosidase activity in Salmonella enterica Typhimurium, both Gram-negative bacteria. Likewise, it was also shown to inhibit biofilm formation in Gram-positive Bacillus cereus. The most likely hypothesis is that Ac2-DPD activity is due to the release of DPD by in situ hydrolysis of the ester groups. Importantly, by contrast with DPD, Ac2-DPD proved to be a stable compound which can be purified and stored.

Ac2-DPD induces bioluminescence in Vibrio harveyi and β-galactosidase activity in Salmonella enterica Typhimurium, and inhibits biofilm formation in Bacillus cereus. Its biological activity is most likely due to in situ hydrolysis into DPD. Ac2-DPD can thus be considered as a stable and storable precursor of DPD.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 5, 1 March 2007, Pages 1428–1431
نویسندگان
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