کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1378038 981992 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Aβ fibril formation
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Aβ fibril formation
چکیده انگلیسی

New bis-styrylpyridine and bis-styrylbenzene derivatives were designed and synthesized. These 34 compounds were evaluated by Aβ fibril formation inhibitory assay using thioflavin T as a dye (named ThT assay). Most of them showed excellent inhibitory activities for Aβ fibril formation at IC50 of 0.1–2.7 μM which is comparable to curcumin (IC50 of 0.8 μM). Among them, nine compounds were screened for their cytotoxicities on HT-22 cell by MTT assay at 1, 10, and 50 μM. In particular, I-7 and II-2 exhibited the best combination of inhibitory activity and compound cytotoxicity.

The new bis-styrylpyridine and bis-styrylbenzene derivatives were designed and synthesized. Most of them showed excellent inhibitory activities for Aβ fibril formation at IC50 of 0.1–2.7 μM which is comparable to curcumin (IC50 of 0.8 μM). In particular, I–7 and II-2 exhibited the best combination of inhibitory activity and compound cytotoxicity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 5, 1 March 2007, Pages 1466–1470
نویسندگان
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