کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1378121 981994 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of acid surrogates toward potency of VLA-4 antagonist
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Influence of acid surrogates toward potency of VLA-4 antagonist
چکیده انگلیسی

A series of VLA-4 antagonist were synthesized wherein carboxylic acid was replaced by various acid surrogates. The effect of these acid surrogates toward potency was evaluated in a binding assay. A number of acid surrogates were potent antagonist of VLA-4, albeit significantly less potent than the corresponding carboxylic acid. Heterocyclic acid surrogate, oxadiazolidinone 3, demonstrated an improved pharmacokinetic property when dosed intravenously.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 18, 15 September 2005, Pages 4053–4056
نویسندگان
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