کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1378224 981996 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New clerodane diterpenoids from Laetia procera (Poepp.) Eichler (Flacourtiaceae), with antiplasmodial and antileishmanial activities
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
New clerodane diterpenoids from Laetia procera (Poepp.) Eichler (Flacourtiaceae), with antiplasmodial and antileishmanial activities
چکیده انگلیسی

Extracts of Laetia procera (Flacourtiaceae) displayed significant in vitro activity against Plasmodium falciparum. P. falciparum bioassay guided fractionation of a trunk bark extract of this plant led to the isolation of six clerodane diterpenoids (1–6) and a butanolide (7). Five of these compounds are new and called Laetiaprocerine A–D (3–6) and Laetianolide A (7). Their structures were established on the basis of 1D and 2D NMR experiments. Absolute configurations of 1 and 2 were determined by a modified Mosher’s method and the absolute configuration of 5 by chemical correlation. The clerodane diterpenoids displayed activities against P. falciparum with an IC50 down to 0.5 μM on FCb1 and F32 strains, and also cytotoxicity toward human tumor cell line MCF7. The most active compound showed a selectivity index of 6.8. Some of these compounds also displayed activities against Leishmania amazonensis amastigote axenic stages and promastigote.

Together with two known compounds, Casearlucine A (1) and Casearmembrol B (2), four new clerodane diterpenoids and one new butanolide have been isolated from Laetia procera (Flacourtiaceae). The six clerodane diterpenoids displayed activities against Plasmodium falciparum, Leishmania amazonensis, and human tumor cell line MCF7.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 22, 15 November 2005, Pages 5065–5070
نویسندگان
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