5-Propynylamino α-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic α-oligonucleotides

Incorporation of 5-propynylamino and 5-propynyl α-2′-deoxyuridine into α-oligonucleotides (α-ON) allows high-affinity targeting of complementary DNA for α-ON with anionic and neutral backbone but not for cationic α-ON, revealing clues on the role of the amino group of the propynylamino on the formation of DNA duplexes.

Incorporation of 5-propynylamino and 5-propynyl α-2′-deoxyuridine into α-oligonucleotides (α-ON) allows high-affinity targeting of complementary DNA for anionic and neutral but not for cationic α-ON.Figure optionsDownload as PowerPoint slide