A convenient and efficient protocol for oxidative aromatization of Hantzsch 1,4-dihydropyridines using benzyltriphenylphosphonium peroxymonosulfate under almost neutral reaction conditions

Oxidative aromatization of 4-alkyl or aryl and heterocyclic-substituted derivatives of Hantzsch 1,4-dihydropyridines to the corresponding pyridine derivatives has been studied using benzyltriphenylphosphonium peroxymonosulfate as an oxidant in the presence of BiCl3 under nearly neutral reaction conditions at ambient temperature.

Aromatization of 1,4-dihydropyridines 1a–l to the corresponding pyridine derivatives 2a–l has been studied using benzyltriphenylphosphonium peroxymonosulfate BTPPMS in the presence of BiCl3 at ambient temperature.Figure optionsDownload as PowerPoint slide