کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1378270 981997 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amplification of DNA-binding affinities of protoberberine alkaloids by appended polyamines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Amplification of DNA-binding affinities of protoberberine alkaloids by appended polyamines
چکیده انگلیسی

This communication describes a synthetic approach toward the amplification of the moderate DNA-binding affinities of protoberberine alkaloids. Specifically, three protoberberine derivatives bearing two to six primary amino groups at the 3- and 9-positions of protoberberine were synthesized and characterized by NMR (1H and 13C) and HRMS. Studies on their affinities toward calf thymus (CT) DNA by ethidium bromide (EB) displacement and spectrophotometric titration experiments indicate that these polyamino protoberberines show more than 103-fold enhanced DNA-binding affinities relative to palmatine and thus are exploitable as strong DNA-binders.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 4, 15 February 2007, Pages 1018–1021
نویسندگان
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