کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1378463 982001 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore
چکیده انگلیسی

A series of tetrahydroisoquinolines acting as dual histamine H3/serotonin transporter ligands is described. A highly regio-selective synthesis of the tetrahydroisoquinoline core involving acid mediated ring-closure of an acetophenone intermediate followed by reduction with NaCNBH3 was developed. In vitro and in vivo data are discussed.

A series of tetrahydroisoquinolines acting as dual histamine H3/serotonin transporter ligands is described. A highly regio-selective synthesis of the tetrahydroisoquinoline core involving acid mediated ring-closure of an acetophenone intermediate followed by reduction with NaCNBH3 was developed. In vitro and in vivo data are discussed.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 3, 1 February 2007, Pages 702–706
نویسندگان
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