کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1378483 | 982001 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chalcone based aryloxypropanolamines as potential antihyperglycemic agents
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A series of chalcone based aryloxypropanolamines were synthesized and evaluated for their antihyperglycemic activity in SLM and STZ rat models. Most of the compounds exhibited moderate to good activity ranging from 6.5% to 31.1% in SLM and 8.3% to 22.6% in STZ models, respectively. The most potent compound 5g exhibited glucose lowering of 26.7% in SLM and 22.6% in STZ models. A definite structure–activity relationship was observed while varying the nature as well as the position of the amine in ring B.
A series of chalcone based aryloxypropanolamines were synthesized which exhibited potent antihyperglycemic activity in SLM and STZ rat models.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 3, 1 February 2007, Pages 799–802
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 3, 1 February 2007, Pages 799–802
نویسندگان
Poonam Shukla, Amar Bahadur Singh, Arvind Kumar Srivastava, Ram Pratap,