کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1378526 982002 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solid-phase synthesis and antibacterial evaluations of N-demethylvancomycin derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Solid-phase synthesis and antibacterial evaluations of N-demethylvancomycin derivatives
چکیده انگلیسی

Twenty-five N-demethylvancomycin derivatives were synthesized on solid-support and their structures were determined by LC–MS/MS. Biological evaluation of these compounds indicated that bulky hydrophobic substituent on vancosamine of N-demethylvancomycin can increase antibacterial activity against vancomycin-resistant Enterococcus faecalis.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 9, 2 May 2005, Pages 2325–2329
نویسندگان
, , , , , ,