New pyrazolo[1′,5′:1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective PDE5 inhibitors

A series of potent PDE5 inhibitors with high selectivity versus PDE6 isoenzymes was identified.

A series of potent PDE5 inhibitors with high selectivity versus PDE6 was identified.Figure optionsDownload as PowerPoint slide