2,3-Diaminopyridine as a platform for designing structurally unique nonpeptide bradykinin B1 receptor antagonists

A novel class of 2,3-diaminopyridine bradykinin B1 receptor antagonists is disclosed. Structure–activity relationship studies (SARs) that led to compounds with significantly improved potency and pharmacokinetic properties relative to the lead compound are described.

A novel class of 2,3-diaminopyridine bradykinin B1 receptor antagonists and related SAR studies are disclosed.Figure optionsDownload as PowerPoint slide