کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1378543 | 982002 | 2005 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase](/preview/png/1378543.png)
Novel potent trisubstituted pyridazine inhibitors of p38 MAP (mitogen activated protein) kinase are described that have activity in both cell-based assays of cytokine release and animal models of rheumatoid arthritis. They demonstrated potent inhibition of LPS-induced TNF-α production in mice and exhibited good efficacy in the rat collagen induced arthritis model.
Novel potent trisubstituted pyridazine inhibitors of p38 MAP (mitogen activated protein) kinase are described that have activity in both cell-based assays of cytokine release and animal models of rheumatoid arthritis. They demonstrated potent inhibition of LPS-induced TNF-α production in mice and exhibited good efficacy in the rat collagen induced arthritis model.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 9, 2 May 2005, Pages 2409–2413