Structure–activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists

SAR studies of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists resulted in potent compounds. The best compound from the series had a binding affinity of 2 nM.

SAR studies of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing receptor antagonists resulted in potent compounds. The best compound from the series had a binding affinity of 2 nM.Figure optionsDownload as PowerPoint slide