کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1378660 982006 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Substituted chromones and quinolones as potent melanin-concentrating hormone receptor 1 antagonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Substituted chromones and quinolones as potent melanin-concentrating hormone receptor 1 antagonists
چکیده انگلیسی

A series of substituted chromones were designed, synthesized, and evaluated for their ability to bind melanin-concentrating hormone receptor 1. Compounds with subnanomolar binding affinity and 66% oral bioavailability in rats were discovered.

A series of substituted chromones were designed, synthesized, and evaluated for their ability to bind melanin-concentrating hormone receptor 1. Compounds with subnanomolar binding affinity and 66% oral bioavailability in rats were discovered.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 16, 15 August 2006, Pages 4237–4242
نویسندگان
, , , , , , , , , , , , ,