کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1378681 982006 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
N-(1,2-Diphenylethyl)piperazines: A new class of dual serotonin/noradrenaline reuptake inhibitor
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
N-(1,2-Diphenylethyl)piperazines: A new class of dual serotonin/noradrenaline reuptake inhibitor
چکیده انگلیسی

The synthesis and structure–activity relationships of a novel series of piperazine derivatives as dual inhibitors of serotonin and noradrenaline reuptake is described. Two compounds possessed comparable in vitro profiles to the dual reuptake inhibitor duloxetine.

The synthesis and structure–activity relationships are described for a series of 20 mono-substituted N-(1,2-diphenylethyl)piperazines as dual serotonin/noradrenaline reuptake inhibitors. Compound 14 possessed a similar in vitro potency selectivity profile to duloxetine.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 16, 15 August 2006, Pages 4345–4348
نویسندگان
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