کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1378716 | 982007 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Benzothiazolium compounds: novel classes of inhibitors that suppress the nitric oxide production in RAW264.7 cells stimulated by LPS/IFNγ
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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![عکس صفحه اول مقاله: Benzothiazolium compounds: novel classes of inhibitors that suppress the nitric oxide production in RAW264.7 cells stimulated by LPS/IFNγ Benzothiazolium compounds: novel classes of inhibitors that suppress the nitric oxide production in RAW264.7 cells stimulated by LPS/IFNγ](/preview/png/1378716.png)
چکیده انگلیسی
A series of benzothiazolium compounds were identified as novel classes of inhibitors of nitric oxide production in a cell culture system. They exhibited ∼1600 folds potency with IC50 at ∼50 nM to several μM as compared to IC50 88.4 μM of l-NMMA, a known inhibitor of nitric oxide synthase. The mechanistic studies suggest that decreased iNOS protein synthesis and mRNA transcription, at least in part, were related to the inhibitory activity of effective benzothiazolium compounds. The correlation of in vivo and in vitro activities using mouse paw edema model was also demonstrated.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 8, 15 April 2005, Pages 2027–2032
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 8, 15 April 2005, Pages 2027–2032
نویسندگان
Huan-Yi Tseng, Ssu-Hui Wu, Wen-Hsin Huang, Shao-Fang Wang, Yung-Ning Yang, Neeraj Mahindroo, Tsu Hsu, Weir-Torn Jiaang, Shiow-Ju Lee,