کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1378729 982007 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design, synthesis and activity of novel derivatives of Oxybutynin and Tolterodine
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design, synthesis and activity of novel derivatives of Oxybutynin and Tolterodine
چکیده انگلیسی

Novel derivatives of Tolterodine (1) and Oxybutynin (2) have been designed using conformationally restricted azabicyclics as replacement for open-chain amines. The synthesis and structure–activity relationships are presented.

Novel analogues of Tolterodine and Oxybutynin are reported using 3-azabicyclo[3.1.0]hexane. The synthesis and SAR highlights our efforts to synthesize a bladder selective muscarinic receptor antagonist.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 8, 15 April 2005, Pages 2093–2096
نویسندگان
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