کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1378874 | 982012 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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![عکس صفحه اول مقاله: Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents](/preview/png/1378874.png)
چکیده انگلیسی
A series of aminoalkoxy phenyl-substituted naphthalene-1-yl-methanone was synthesized and tested for its anti-hyperglycemic activity in SLM and STZ-S rat models. Some compounds (3b, 4c and 4h) of the series were showing significant anti-hyperglycemic activity in male Sprague–Dawley rats in sucrose-loaded model (SLM) as well as in streptozotocin-induced model (STZ-S). Active compounds were also evaluated for relative binding affinity against glucagon receptor.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 10, 15 May 2006, Pages 2719–2723
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 10, 15 May 2006, Pages 2719–2723
نویسندگان
Atul Kumar, S.R. Pathak, Pervez Ahmad, S. Ray, P. Tewari, A.K. Srivastava,