Three anti-tumor saponins from Albizia julibrissin

Three new triterpenoid saponins, julibroside J29 (1), julibroside J30 (2), and julibroside J31 (3), were isolated from the stem bark of Albizia julibrissin Durazz. (Leguminosae) by using chromatographic method. Their structures were established by spectroscopic methods. Compounds 1, 2, and 3 displayed significant anti-tumor activities in vitro against PC-3M-1E8, HeLa, and MDA-MB-435 cancer cell lines at 10 μM assayed by SRB and MTT methods.

The structures of three new triterpenoid saponins, julibroside J29, julibroside J30, and julibroside J31, isolated from Albizia julibrissin, have been determined on the basis of comprehensive spectroscopic analysis. They had marked anti-tumor activity.Figure optionsDownload as PowerPoint slide