Synthesis and biological evaluation of gemcitabine–lipid conjugate (NEO6002)

A novel gemcitabine–lipid conjugate 5 was synthesized and tested for its in vivo efficacy and toxicity. Compound 5 was tested in BxPC-3 human pancreatic tumor model in SCID mice and exhibited promising activity and lower toxicity when compared with Gemzar®.

The synthesis and biological evaluation of novel gemcitabine–lipid conjugate is reported.Figure optionsDownload as PowerPoint slide