Identification of chemokine receptor CCR4 antagonist

The present study reports the identification and hits to leads optimization of chemokine receptor CCR4 antagonists. Compound 12 is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor.

The present study reports the identification and hits to leads optimization of CCR4 antagonists. The compound shown is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor.Figure optionsDownload as PowerPoint slide