Synthesis and evaluation of an N-acylated photoactivatable analogue of glutathione as probe for glutathione-utilizing enzymes

The first synthesis of an N-acylated photoactivatable analogue of reduced glutathione is described. N-(4-Benzoylbenzoyl)glutathione (8) was found to be an inhibitor and a photoaffinity probe of purified rat liver glutathione S-transferases.

The synthesis of N-(4-benzoylbenzoyl)glutathione an inhibitor and a photoaffinity probe of purified rat liver glutathione S-transferases is reported.Figure optionsDownload as PowerPoint slide