Depeptidization efforts on P3–P2′ α-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity

Depeptidization efforts of the P3–P2 region of P3 capped α-ketoamide inhibitor of HCV NS3 serine protease 1 are reported. We clearly established that N-methylation of the P2 nitrogen and modification of the P2′ carboxylic acid terminus were essential for activity in the replicon assay.

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