کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1379236 | 982022 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of 2,5-thiazole butanoic acids as potent and selective αvβ3 integrin receptor antagonists with improved oral pharmacokinetic properties
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
We describe a series of 2,5 thiazole containing compounds, which are potent antagonists of the integrin αvβ3 and show selectivity relative to the other integrins, such as αIIbβ3 and αvβ6. These analogs were demonstrated to have high bioavailability relative to other relative heterocyclic analogs.
A series of 2,5 thiazole containing compounds are described, which are potent antagonists of the integrin αvβ3 and show selectivity relative to the other integrins, such as αIIbβ3 and αvβ6. These analogs were demonstrated to have high bioavailability relative to other relative heterocyclic analogs.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 4, 15 February 2006, Pages 845–849
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 4, 15 February 2006, Pages 845–849
نویسندگان
John A. Wendt, Hongwei Wu, Heather G. Stenmark, Mark L. Boys, Victoria L. Downs, Thomas D. Penning, Barbara B. Chen, Yaping Wang, Tiffany Duffin, Mary Beth Finn, Jeffery L. Keene, V. Wayne Engleman, Sandra K. Freeman, Melanie L. Hanneke,