Discovery of a potent phenolic N1-benzylidene–pyridinecarboxamidrazone selective against Gram-positive bacteria

As part of a study into antimycobacterial compounds a set of phenolic N1-benzylidene–pyridinecarboxamidrazones was prepared and evaluated. This report describes the unexpected discovery of a potent compound with a pronounced selectivity for Gram-positive bacteria over Gram-negative micro-organisms. In addition, this compound is active against various drug-resistant Gram-positive bacteria.

The discovery of a potent phenolic N1-benzylidene–pyridinecarboxamidrazone is presented, which has a pronounced selectivity for Gram-positive bacteria over Gram-negative microorganisms and activity against various drug-resistant Gram-positive bacteria.Figure optionsDownload as PowerPoint slide