Design, synthesis, and evaluation of 2-alkoxydihydrocinnamates as PPAR agonists

A series of 2-alkoxydihydrocinnamates were synthesized as PPARγ and PPARα dual agonists. In vitro studies in cell model showed that these compounds were efficacious. Compound 1g was found to be a potent PPARα/γ dual agonist and will be further evaluated for the treatment of type II diabetes.

A series of 2-alkoxydihydrocinnamates as PPARγ and PPARα dual agonists with substituted biphenyl tailpiece were synthesized and tested for their functional activity in vitro.Figure optionsDownload as PowerPoint slide