Synthesis of complex-type glycans derived from parasitic helminths

Chemical synthesis of complex-type glycans 1 and 2 derived from eggs of parasitic helminths, Schistosoma mansoni and Schistosoma japonicum, is described. These branched sugar chains were synthesized regio- and stereoselectively by using β-mannosylation, desilylation under high pressure, and glycosylation in frozen solvent as key transformations.

Synthesis of branched complex-type glycans derived from helminth glycoproteins is described.Figure optionsDownload as PowerPoint slide