کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1379380 982027 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of a potent and selective 5-HT1B receptor antagonist
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Identification of a potent and selective 5-HT1B receptor antagonist
چکیده انگلیسی

An SAR study around the mixed 5-HT1ABD receptor antagonist SB-272183 found that introduction of cis-2,6-dimethyl substitution onto the piperazine ring was a key structural change, which imparted a combination of both excellent selectivity over the 5-HT1A and 5-HT1D receptors and low intrinsic activity. This led to the identification of the selective 5-HT1B receptor antagonist SB-616234.

Introduction of cis-2,6-dimethyl substitution onto the piperazine ring of a mixed 5-HT1ABD receptor antagonist offers a combination of both excellent selectivity over 5-HT1A and 5-HT1D receptors and low intrinsic activity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 21, 1 November 2005, Pages 4708–4712
نویسندگان
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