کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1379390 982027 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex
چکیده انگلیسی

The activated Factor VII/tissue factor complex (FVIIa/TF) plays a key role in the formation of blood clots. Inhibition of this complex may lead to new antithrombotic drugs. An X-ray crystal structure of a fluoropyridine-based FVIIa/TF inhibitor bound in the active site of the enzyme complex suggested that incorporation of substitution at the 5-position of the hydroxybenzoic acid side chain could lead to the formation of more potent inhibitors through interactions with the S1′/S2′ pocket.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 21, 1 November 2005, Pages 4752–4756
نویسندگان
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