کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1379410 982027 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of a biotinylated camptothecin derivative and determination of the binding sequence by T7 phage display technology
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of a biotinylated camptothecin derivative and determination of the binding sequence by T7 phage display technology
چکیده انگلیسی

A biotinylated derivative of the anti-tumor agent camptothecin (CPT) was synthesized and used in a phage display assay to identify drug-binding sequences. After three rounds of selection using C20-biotinylated CPT (CPT-20-B) as bait, a CPT-20-B-binding sequence, NSSQSARR, was identified.

Synthesis of CPT-20-B and peptide screening by T7 phage display method have been reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 21, 1 November 2005, Pages 4846–4849
نویسندگان
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