کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1379413 982027 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Conformationally restricted anti-plasmodial chalcones
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Conformationally restricted anti-plasmodial chalcones
چکیده انگلیسی

Chalcones can exist as Z- or E-isomers and it is generally anticipated that both isomers are equipotent. In order to determine the active isomer of anti-plasmodial chalcones a series of analogues locked in the Z- or the E-form were prepared and evaluated for their anti-plasmodial activity. It was shown that the Z-locked analogue was nearly inactive, whereas the E-locked analogues were equipotent to the parent chalcones, indicating that the E-isomer is the active conformation.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 21, 1 November 2005, Pages 4858–4861
نویسندگان
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