کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1379563 982032 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P2′ moiety with improved potency
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P2′ moiety with improved potency
چکیده انگلیسی

We have discovered that introduction of appropriate amino acid derivatives at P2′ position improved the binding potency of P3-capped α-ketoamide inhibitors of HCV NS3 serine protease. X-ray crystal structure of one of the inhibitors (43) bound to the protease revealed the importance of the P2′ moiety.

Introduction of appropriate amino acid derivatives at P′2 position improved the binding potency of P3-capped α-ketoamide inhibitors of HCV NS3 serine protease. X-ray crystal structure of one of the inhibitors (43) bound to the protease revealed the importance of the P′2 moiety.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 19, 1 October 2005, Pages 4180–4184
نویسندگان
, , , , , , , , , , , , , , , , , , , , , ,