کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1379570 982032 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cyclic sulfamide γ-secretase inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Cyclic sulfamide γ-secretase inhibitors
چکیده انگلیسی

A novel series of N-alkyl-substituted cyclic sulfamides were developed from a screening hit. Chemistries were developed which allowed surveys of N-alkyl groups and amines resulting in the identification of N-trifluoroethyl-substituted cyclic sulfamides with good in vitro and in vivo γ-secretase activity. One compound with subnanomolar activity elicited a reduction in brain Aβ40 after oral dosing in APP-YAC mice.

A novel series of N-alkyl-substituted cyclic sulfamides were developed from a screening hit.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 19, 1 October 2005, Pages 4212–4216
نویسندگان
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