Dipyridyl amines: Potent metabotropic glutamate subtype 5 receptor antagonists

Modulation of the metabotropic glutamate subtype 5 (mGlu5) receptor may be useful in the treatment of a variety of central nervous system disorders. Herein, we report on the discovery, synthesis, and biological evaluation of dipyridyl amines as small molecule mGlu5 antagonists.

The metabotropic glutamate subtype 5 (mGlu5) receptor has been implicated in a number of CNS disorders. Herein, we report on the discovery, synthesis, and biological evaluation of dipyridyl amines as small molecule mGlu5 antagonists.Figure optionsDownload as PowerPoint slide