کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1379609 982032 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epibatidine analogues as selective ligands for the αxβ2-containing subtypes of nicotinic acetylcholine receptors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Epibatidine analogues as selective ligands for the αxβ2-containing subtypes of nicotinic acetylcholine receptors
چکیده انگلیسی

A series of epibatidine analogues was synthesized and characterized in vitro. These compounds are high affinity ligands for the nicotinic acetylcholine receptors (nAChR). They display binding selectivity for the αxβ2 subtypes of nAChRs over the αxβ4 subtypes, and especially for the α4β2 and α2β2 subtypes. Furthermore, most of these new nicotinic compounds display little, if any, agonist activities at α3β4 nAChR. As a result they might become lead structures for the design and synthesis of highly selective ligands for nAChR subtypes containing the β2 subunit.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 19, 1 October 2005, Pages 4385–4388
نویسندگان
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