کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1379696 | 982037 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
DNA binding specificity and cytotoxicity of novel antitumor agent Ge132 derivatives
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A series of Ge132 derivatives have shown enhanced antitumor activity. Previous studies suggest that DNA can be their primary target. Here we show direct evidence that two newly synthesized Ge132 derivatives can intercalate into DNA. Unexpected methyl substitution effect of the novel derivatives on DNA sequence selectivity and cytotoxicity was observed.
Two newly synthesized Ge132 derivatives can greatly enhance their DNA binding. Unexpected methyl substitution effect on DNA sequence selectivity and cytotoxicity was observed.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 12, 15 June 2005, Pages 2962–2965
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 12, 15 June 2005, Pages 2962–2965
نویسندگان
Guoqiang Shangguan, Feifei Xing, Xiaogang Qu, Jianhua Mao, Dan Zhao, Xuejian Zhao, Jinsong Ren,