کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1393530 1501224 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metal complexes of retinoid derivatives with antiproliferative activity: Synthesis, characterization and DNA interaction studies
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Metal complexes of retinoid derivatives with antiproliferative activity: Synthesis, characterization and DNA interaction studies
چکیده انگلیسی

9-cis-Retinal thiosemicarbazone and its Co(III), Ni(II) and Cu(II) complexes are synthesized and characterized. Central Co(III) atom is in an octahedral environment while Ni(II) and Cu(II) atoms are in a square planar environment. DNA binding constants and spectroscopic data show an intercalative behavior for the nickel complex; an external binding mode is envisaged for the ligand and its copper complex. No DNA interaction can be hypothesized for the cobalt complex. The free ligand and its Ni(II) and Cu(II) complexes have a good lipophilic degree for an efficient uptake by the cells. The metal complexes exhibit a proliferation inhibition action against cell line U937 at micromolar concentration. Cu(II) complex also induces apoptosis, while Ni(II) complex has a strong interaction with CT-DNA.

The syntheses and characterization of 9-cis-retinal thiosemicarbazone Hret and its Co(III), Ni(II) and Cu(II) complexes are reported. The metal complexes exhibit a proliferation inhibition action against human tumor cell line U937 at micromolar concentration. Cu(II) complex also induces apoptosis.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 42, Issue 5, May 2007, Pages 627–634
نویسندگان
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