کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1394615 1501174 2011 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of DNA binding, DNA cleavage, protein binding and in vitro cytotoxic activities of bivalent transition metal hydrazone complexes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Evaluation of DNA binding, DNA cleavage, protein binding and in vitro cytotoxic activities of bivalent transition metal hydrazone complexes
چکیده انگلیسی

Divalent Co, Ni and Cu hydrazone complexes containing [N′-(phenyl(pyridine-2-yl)methylidene) benzohydrazide] ligand were synthesised and characterised. Interactions of these complexes with DNA revealed an intercalative mode of binding between them. Further, all the hydrazone chelates showed moderate ability to cleave pUC19 DNA. Synchronous fluorescence spectra proved that the interaction of metal complexes with bovine serum albumin (BSA) resulted in a conformational change of the latter. Assay on the cytotoxicity of the above complexes against HeLa tumor cells and NIH 3T3 normal cells revealed that the complexes are toxic only against tumor cells but not to normal cells. In all the biological assays, the complex with copper ion as the metal center showed enhanced activities than the other two.

Synthesis, structural elucidation and interaction with DNA, protein, cytotoxicity studies were carried out on biologically important transition metal hydrazone complexes.Figure optionsDownload as PowerPoint slideHighlights
► Synthesis of new transition metal hydrazone complexes with octahedral geometry.
► All the new complexes showed significant interaction with both DNA and protein.
► Cytotoxicity results proved their efficacy against HeLa tumor cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 46, Issue 8, August 2011, Pages 3376–3387
نویسندگان
, , , , ,