کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1395008 1501192 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands
چکیده انگلیسی

An easy and convenient microwave-assisted synthesis of a small library of indolic arylpiperazine derivatives is described. Parallel and mixed pool combinatorial methods are reported and compared. The described reactions are nucleophilic substitutions of several aromatic piperazines in presence of K2CO3. Good yields and short reaction times are the main aspect of these procedures. Binding assays shed additional light on the influence of the LCAPs on the 5-HT1A, 5-HT2A and 5-HT2C receptors affinity and allowed to disclose three interesting compounds as 5-HT2C, mixed 5-HT2A/5-HT2C and 5-HT1A/5-HT2C ligands (4i, 4l and 4d, respectively), with potential antiepileptic, anxiolytic or atypical antipsychotic agent therapeutical profiles.

An easy and convenient microwave-assisted synthesis of a small library of indolic arylpiperazine derivatives as 5-HT2C, mixed 5-HT2A/5-HT2C and 5-HT1A/5-HT2C ligands.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 2, February 2010, Pages 752–759
نویسندگان
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