کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1395190 1501202 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hydroxychalcones induce apoptosis in B16-F10 melanoma cells via GSH and ATP depletion
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Hydroxychalcones induce apoptosis in B16-F10 melanoma cells via GSH and ATP depletion
چکیده انگلیسی

Searching for leading compounds of new drugs for cancer therapy, we studied the toxicity of 13 hydroxychalcones never tested before toward melanoma cell line (B16-F10). The compounds were obtained by aldolic condensation between aldehydes and hydroxylated acetophenones, in alkaline conditions. Three of them showed cytotoxicity to the cell line. Two of them induced mitochondrial GSH and ATP depletion and promoted cell death through apoptosis in melanoma cells. One of the compounds induced cell death through necrosis but did not significantly decrease the intracellular mitochondrial GSH and ATP levels in melanoma cells. The results suggest that the predominant factor for the activity is the molecule shape, and secondarily the number of hydroxyl groups.

Hydroxychalcones were tested toward a melanoma cell line. The compounds induced mitochondrial GSH and ATP depletion, and cell apoptosis. The molecule shape and the number of hydroxyl groups are important for the activity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 4, April 2009, Pages 1630–1637
نویسندگان
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